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KMID : 1024420210250040289
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Food Engineering Progress
2021 Volume.25 No. 4 p.289 ~ p.296
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Rapid Extraction of Bacteriocins using Aqueous Two-Phase System: A Literature Review
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Kim Jong-Hui
Lee Eun-Seon
Kim Bu-Min
Ham Jun-Sang
Oh Mi-Hwa
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Abstract
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Bacteriocins are ribosomally synthesized proteinaceous substances produced by bacteria. They exhibit antimicrobial activity against closely related species and food-borne pathogens. Those produced by lactic acid bacteria (LAB) suggest a new direction for food preservation as they are often employed in food processing and food fermentations as natural biopreservatives. However, this new market demands the development of new downstream strategies to maximize its efficiency and economics. Aqueous two-phase system (ATPS) is a liquid-liquid fractionation technique, which has emerged as a powerful tool for the efficient extraction and purification of peptides, enzymes, and proteins due to its versatility, lower cost, process integration capability, and ease to scale-up. In this review, we introduce polymer-salt ATPS and surfactant-assisted ATPS for bacteriocin separation and provide an overview of the effects of parameters such as tie line length, pH, and properties of polymers and salts.
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KEYWORD
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Bacteriocin, Rapid extraction, Aqueous two-phase system, ATPS
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